Abstract: OBJECTIVE: To investigate radiation-protective effect of piceatannol and acetylated resveratrol. METHODS：CCK-8 Assay Kit was used to detect the survival rate of AHH-1 cells treated by 0，10，20，50，100 and 500 μmol/L piceatannol or acetylated resveratrol for 72 h，or by 4 Gy γ-ray for 48 h after treatment with 0，10，20 and 50 μmol/L piceatannol or acetylated resveratrol for 2 h. Kunming mice were treated with resveratrol，piceatannol and acetylated resveratrol before 60Co γ-irradiation. The average life span and the WBC count post-irradiation were observed. RESULTS：Compared to control cells (0 μmol/L)，the survival rate of AHH-1 cells treated by 10，20 and 50 μmol/L piceatannol or acetylated resveratrol for 72 h was not changed (P>0.05)，but the survival rate of post-irradiation AHH-1 cells treated by 10，20 and 50 μmol/L piceatannol or acetylated resveratrol increased (P<0.05 or P<0.01). After radiation for 24 h，the WBC count of middle-dose (100 mg/kg) and high-dose(200 mg/kg) acetylated resveratrol groups increased (P<0.05). Compared to control group (0 μmol/L)，the average life span and the WBC count of radiation group decreased (P<0.05). Compared to radiation group，the average life span of mice in high-dose resveratrol or acetylated resveratrol groups increased. CONCLUSION：Piceatannol and acetylated resveratrol both had radiation-protective effect in post-radiation AHH-1 cells. In addition，acetylated resveratrol showed radiation-protective effect in post-radiation Kunming mice.

Key words: resveratrol, piceatannol, acetylated resveratrol, radiation, AHH-1